Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13570773 | 0.81 | MAPT (0.52) | MAPTHTTFGFR4MAPK1NPC1 | |
| SCHEMBL2177085 | 0.78 | FGFR4 (0.45) | MAPTHTTFGFR4MAPK1NPC1 | |
| SCHEMBL2173853 | 0.77 | MAPT (0.48) | MAPTHTTFGFR4MAPK1NPC1 | |
| SCHEMBL9983193 | 0.74 | FGFR4 (0.52) | MAPTHTTFGFR4MAPK1NPC1 | |
| SCHEMBL13570477 | 0.73 | FGFR4 (0.54) | MAPTHTTFGFR4MAPK1NPC1 | |
| SCHEMBL2175624 | 0.73 | FGFR4 (0.39) | MAPTHTTFGFR4MAPK1NPC1 | |
| SCHEMBL718271 | 0.73 | MAPT (0.51) | MAPTHTTFGFR4MAPK1NPC1 | |
| SCHEMBL30826628 | 0.73 | MAPT (0.47) | MAPTHTTFGFR4MAPK1NPC1 | |
| SCHEMBL22719050 | 0.72 | MAPT (0.54) | MAPTHTTFGFR4MAPK1NPC1 | |
| SCHEMBL29535826 | 0.72 | MAPT (0.54) | MAPTHTTFGFR4MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519522-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |