Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13570773 | 0.81 | MAPT (0.52) | MAPTHTTFGFR4MEN1KMT2A | |
| SCHEMBL2173851 | 0.77 | MAPT (0.49) | MAPTHTTFGFR4MEN1KMT2A | |
| SCHEMBL2177090 | 0.77 | MAPT (0.44) | MAPTHTTFGFR4MEN1KMT2A | |
| SCHEMBL30826628 | 0.75 | MAPT (0.47) | MAPTHTTFGFR4MEN1KMT2A | |
| SCHEMBL13570772 | 0.74 | MAPT (0.51) | MAPTHTTFGFR4MEN1KMT2A | |
| SCHEMBL27227387 | 0.73 | GSK3A (0.59) | MAPTHTTFGFR4MEN1KMT2A | |
| SCHEMBL9983193 | 0.73 | FGFR4 (0.52) | MAPTHTTFGFR4MEN1KMT2A | |
| SCHEMBL2174279 | 0.72 | MAPT (0.43) | MAPTHTTFGFR4MEN1KMT2A | |
| SCHEMBL2189170 | 0.72 | MAPT (0.43) | MAPTHTTFGFR4MEN1KMT2A | |
| SCHEMBL19666472 | 0.72 | PIN1 (0.61) | MAPTMEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |