Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12597673 | 0.85 | LMNA (0.42) | LMNAMEN1KMT2ANPSR1MAPT | |
| SCHEMBL12208145 | 0.83 | LMNA (0.44) | LMNAMEN1KMT2ANPSR1MAPT | |
| SCHEMBL27831964 | 0.81 | LMNA (0.44) | LMNAMEN1KMT2ANPSR1MAPT | |
| SCHEMBL27811655 | 0.81 | LMNA (0.44) | LMNAMEN1KMT2ANPSR1MAPT | |
| SCHEMBL735218 | 0.80 | MAPT (0.45) | LMNAMEN1KMT2ANPSR1MAPT | |
| SCHEMBL13318603 | 0.77 | MAPT (0.43) | LMNAMEN1KMT2ANPSR1MAPT | |
| SCHEMBL735221 | 0.77 | CA1 (0.53) | LMNAMEN1KMT2ANPSR1MAPT | |
| SCHEMBL9240301 | 0.77 | LMNA (0.44) | LMNAMEN1KMT2ANPSR1MAPT | |
| SCHEMBL8093263 | 0.76 | CA1 (0.50) | LMNAMEN1KMT2ANPSR1MAPT | |
| SCHEMBL20279655 | 0.72 | MAPT (0.43) | LMNAMEN1KMT2ANPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390415-B1 | (R)- AND (S)-1-(3-(3-N,N-DIMETHYLAMINOCARBONYL)PHENOXYL-4-NITROPHENYL)-1-ETHYL-N,N'-BIS (ETHYLENE)PHOSPHORAMIDATE, COMPOSITIONS AND METHODS FOR THEIR USE AND PREPARATION | OBI PHARMA INC (TW) | 2020-02-26 | — | — | EP | disclosed |