Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174568 | 0.83 | EGFR (0.71) | EGFRMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2175165 | 0.82 | EGFR (1.00) | EGFRMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2176219 | 0.80 | EGFR (0.67) | EGFRMEN1KMT2ALMNAMAPK1 | |
| SCHEMBL27318793 | 0.80 | EGFR (0.67) | EGFRMEN1KMT2ATNNI3KNPC1 | |
| SCHEMBL1095000 | 0.78 | EGFR (0.78) | EGFRERBB2ERBB3 | |
| SCHEMBL374504 | 0.78 | EGFR (0.64) | EGFRMEN1KMT2ALMNAKDM4E | |
| SCHEMBL2389236 | 0.77 | MEN1 (0.56) | EGFRMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2279563 | 0.77 | MEN1 (0.56) | EGFRMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL1096794 | 0.76 | ERBB2 (0.59) | EGFRERBB2 | |
| SCHEMBL12517438 | 0.76 | TNNI3K (0.82) | EGFRTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519501-A2 | SUBSTITUTED PYRIDINES AND PYRIMIDINES FOR THE PRODUCTION OF CARDIOMYOCYTE-LIKE CELLS | Technische Universität Wien (AT) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011079343-A2 | SUBSTITUTED PYRIDINES AND PYRIMIDINES | TECHNISCHE UNIVERSITAET WIEN (AT) | 2011-07-07 | — | — | WO | disclosed |