Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 6/20 | 0.37 |
| ▸ | ABL1 | P00519 | 5/20 | 0.37 |
| ▸ | HCK | P08631 | 5/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 6/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | MTOR | P42345 | 4/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20093561 | 0.83 | BTK (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL30415808 | 0.79 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGBTK | |
| SCHEMBL21386702 | 0.79 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGBTK | |
| SCHEMBL13717931 | 0.78 | SRC (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL13717800 | 0.77 | CSNK1E (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL20093481 | 0.77 | KMO (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL21364711 | 0.77 | MAP4K4 (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL19414297 | 0.76 | PIK3CD (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL3782102 | 0.74 | PIK3CD (0.57) | MAPK1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30387175 | 0.73 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3828184-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AND USE THEREOF AS PI3K INHIBITOR | Medshine Discovery Inc. (CN) | 2021-06-02 | — | — | EP | disclosed |
| WO-2020038394-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AND USE THEREOF AS PI3K INHIBITOR | 南京明德新药研发有限公司 | 2020-02-27 | — | — | WO | disclosed |