Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 10/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 10/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.30 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.30 |
| ▸ | RPS17 | P08708 | 1/20 | 0.30 |
| ▸ | RPSA | P08865 | 1/20 | 0.30 |
| ▸ | RPS2 | P15880 | 1/20 | 0.30 |
| ▸ | RPL35A | P18077 | 1/20 | 0.30 |
| ▸ | RPL7 | P18124 | 1/20 | 0.30 |
| ▸ | RPL17 | P18621 | 1/20 | 0.30 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.30 |
| ▸ | RPS3 | P23396 | 1/20 | 0.30 |
| ▸ | RPS12 | P25398 | 1/20 | 0.30 |
| ▸ | RPL13 | P26373 | 1/20 | 0.30 |
| ▸ | RPL10 | P27635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21773165 | 0.85 | SCN8A (0.42) | SCN1ASCN8A | |
| SCHEMBL21772996 | 0.78 | SCN8A (0.69) | SCN1ASCN8A | |
| SCHEMBL21789061 | 0.77 | SCN8A (0.43) | SCN1ASCN8ASLC6A4SLC6A2KCNH2 | |
| Formic Acid SCHEMBL30845609 | 0.76 | SCN8A (0.57) | SCN1ASCN8A | |
| Formic Acid SCHEMBL28564571 | 0.76 | SCN8A (0.57) | SCN1ASCN8A | |
| Formic Acid SCHEMBL21773131 | 0.76 | SCN8A (0.57) | SCN1ASCN8A | |
| SCHEMBL21773121 | 0.75 | NPC1 (0.32) | SCN1ASCN8A | |
| SCHEMBL21777202 | 0.75 | SCN8A (0.35) | SCN1ASCN8A | |
| SCHEMBL28559498 | 0.69 | SCN8A (0.37) | SCN1ASCN8A | |
| SCHEMBL19613601 | 0.67 | SCN8A (0.42) | SCN1ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752623-B2 | Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors | XENON PHARMACEUTICALS INC. (CA) | 2020-08-25 | — | — | US | disclosed |
| US-20200071313-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071313-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS | SCN1A, SCN2A, SCN2B | SCN1A 1/4885SCN8A 6/4885SLC6A4 121/4885 |
| US-10752623-B2 | Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors | SCN1A, SCN2A, SCN2B | SCN1A 1/4885SCN8A 6/4885SLC6A4 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.