Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.43 |
| ▸ | CCNC | P24863 | 3/20 | 0.42 |
| ▸ | CDK8 | P49336 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179297 | 0.87 | EIF2AK2 (0.41) | EZH2CCNCCDK8 | |
| SCHEMBL12489865 | 0.86 | EZH2 (0.41) | EZH2CCNCCDK8 | |
| SCHEMBL2177296 | 0.86 | CCNC (0.42) | EZH2CCNCCDK8MAPK10 | |
| SCHEMBL12489870 | 0.85 | EZH2 (0.41) | EZH2CCNCCDK8MAPK10 | |
| SCHEMBL6126567 | 0.85 | IKBKB (0.48) | EZH2MAPK10 | |
| SCHEMBL2178208 | 0.84 | EZH2 (0.40) | EZH2CCNCCDK8 | |
| SCHEMBL2181275 | 0.84 | EZH2 (0.40) | EZH2CCNCCDK8 | |
| SCHEMBL2179145 | 0.84 | EZH2 (0.42) | EZH2CCNCCDK8MAPK10 | |
| SCHEMBL2180806 | 0.84 | JAK2 (0.43) | EZH2CCNCCDK8 | |
| SCHEMBL2178619 | 0.83 | EZH2 (0.41) | EZH2CCNCCDK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173808-B2 | Substituted naphthalenyl-pyrimidine compounds | ARQULE, INC. (US) | 2012-05-08 | — | — | US | claimed |
| US-8173808-B2 | Substituted naphthalenyl-pyrimidine compounds | ARQULE, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-8173808-B2 | Substituted naphthalenyl-pyrimidine compounds | ARQULE, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| WO-2011082268-A2 | SUBSTITUTED NAPHTHALENYL-PYRIMIDINE COMPOUNDS | ARQULE INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | DPYD, TP53, TYMP | PHGDH 984/4885EZH2 1761/4885PDE10A 2247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.