Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.48 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179297 | 0.89 | EIF2AK2 (0.41) | EZH2EIF2AK2EHMT1MKNK1 | |
| SCHEMBL2176320 | 0.88 | NOS3 (0.41) | IKBKBEZH2EIF2AK2MKNK1CDK2 | |
| SCHEMBL2175893 | 0.88 | MKNK1 (0.51) | IKBKBEIF2AK2MAPK14MKNK1CDK4 | |
| SCHEMBL6125386 | 0.87 | IKBKB (0.51) | IKBKBMAPK14RETCDK4CCND1 | |
| SCHEMBL2179393 | 0.87 | EHMT1 (0.40) | IKBKBEZH2EIF2AK2EHMT1MKNK1 | |
| SCHEMBL2179213 | 0.86 | EIF2AK2 (0.39) | IKBKBEZH2EIF2AK2EHMT1MKNK1 | |
| SCHEMBL12489868 | 0.86 | EIF2AK2 (0.39) | IKBKBEZH2EIF2AK2MKNK1 | |
| SCHEMBL12489870 | 0.86 | EZH2 (0.41) | EZH2EIF2AK2MKNK1KCNH2MAPK10 | |
| SCHEMBL12489865 | 0.85 | EZH2 (0.41) | EZH2EIF2AK2MKNK1 | |
| SCHEMBL12486630 | 0.85 | CCNC (0.38) | IKBKBEZH2EIF2AK2RETMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173808-B2 | Substituted naphthalenyl-pyrimidine compounds | ARQULE, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | DPYD, TP53, TYMP | IKBKB 401/4885EZH2 1761/4885EIF2AK2 1269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.