Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19617362 | 0.94 | KMT2A (0.34) | KMT2AGAAHTTCYP1A2CYP2C19 | |
| SCHEMBL21777078 | 0.89 | CCNA2 (0.37) | KMT2AGAAHTT | |
| SCHEMBL30421713 | 0.84 | TMEM97 (0.41) | KMT2AGAA | |
| SCHEMBL30421340 | 0.84 | TMEM97 (0.41) | KMT2AGAA | |
| SCHEMBL19617493 | 0.82 | PARP1 (0.40) | KMT2A | |
| SCHEMBL26010448 | 0.81 | KMT2A (0.36) | KMT2AGAACYP1A2CYP2C19 | |
| SCHEMBL21315024 | 0.81 | — | — | |
| SCHEMBL28503146 | 0.79 | KMT2A (0.31) | KMT2AGAACYP1A2CYP2C19 | |
| SCHEMBL28535555 | 0.78 | C5AR1 (0.41) | KMT2AGAAHTTCYP1A2 | |
| SCHEMBL4192572 | 0.78 | CCNA2 (0.39) | KMT2ACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3844151-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020047192-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-03-05 | — | — | WO | disclosed |