Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 2/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1275908 | 0.83 | HTR2C (0.47) | HTR2CHTR2AHTR2BPNMTKEAP1 | |
| SCHEMBL31393901 | 0.81 | AVPR1A (0.42) | HTR2CHTR2AHTR2BKEAP1NFE2L2 | |
| SCHEMBL29190476 | 0.79 | SLC6A4 (0.41) | KEAP1NFE2L2AVPR1AOXTRKDM1A | |
| SCHEMBL16939880 | 0.79 | AVPR1A (0.36) | AVPR1AADRA2AHTR5A | |
| SCHEMBL30098011 | 0.79 | PNMT (0.40) | HTR2CHTR2AHTR2BPNMTAHR | |
| SCHEMBL15505712 | 0.79 | PNMT (0.40) | HTR2CHTR2AHTR2BPNMTAHR | |
| Hydrochloric Acid SCHEMBL19616590 | 0.78 | PNMT (0.39) | HTR2CHTR2AHTR2BPNMTAHR | |
| SCHEMBL24842401 | 0.76 | CD274 (0.36) | — | |
| SCHEMBL24203802 | 0.76 | ATM (0.40) | KEAP1NFE2L2AVPR1AOXTRKDM1A | |
| SCHEMBL24203780 | 0.76 | AVPR1A (0.44) | KEAP1NFE2L2AVPR1AOXTRKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332492-B2 | CD73 inhibitors and therapeutic uses thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2022-05-17 | — | — | US | disclosed |
| US-11332492-B2 | CD73 inhibitors and therapeutic uses thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2022-05-17 | — | — | US | disclosed |
| US-20210253621-A1 | CD73 INHIBITORS AND THERAPEUTIC USES THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2021-08-19 | — | — | US | disclosed |
| US-20210253621-A1 | CD73 INHIBITORS AND THERAPEUTIC USES THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2021-08-19 | — | — | US | disclosed |
| EP-3843742-A1 | CD73 INHIBITORS AND THERAPEUTIC USES THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020047082-A1 | CD73 INHIBITORS AND THERAPEUTIC USES THEREOF | Eternity Bioscience Inc. (US) | 2020-03-05 | — | — | WO | disclosed |
| WO-2020047082-A1 | CD73 INHIBITORS AND THERAPEUTIC USES THEREOF | Eternity Bioscience Inc. (US) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253621-A1 | CD73 INHIBITORS AND THERAPEUTIC USES THEREOF | ENTPD5, ENTPD1, NT5E | HTR2C 3129/4885HTR2A 2451/4885HTR2B 2342/4885 |
| US-11332492-B2 | CD73 inhibitors and therapeutic uses thereof | ENTPD5, ENTPD1, NT5E | HTR2C 3129/4885HTR2A 2451/4885HTR2B 2342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.