Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 14/20 | 0.36 |
| ▸ | AXL | P30530 | 10/20 | 0.36 |
| ▸ | MERTK | Q12866 | 9/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 8/20 | 0.36 |
| ▸ | MST1R | Q04912 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722856 | 0.86 | PDE1B (0.37) | F10F2CTRB1ALDH1A1MET | |
| SCHEMBL30693661 | 0.80 | AXL (0.58) | METAXLMERTKTYRO3 | |
| SCHEMBL3103995 | 0.80 | AXL (0.58) | METAXLMERTKTYRO3 | |
| SCHEMBL30208939 | 0.77 | AXL (0.57) | METAXLMERTKTYRO3 | |
| SCHEMBL21785971 | 0.77 | AXL (0.57) | METAXLMERTKTYRO3 | |
| SCHEMBL1944519 | 0.75 | AXL (0.38) | METAXL | |
| SCHEMBL3106815 | 0.74 | MET (0.59) | METMST1R | |
| SCHEMBL3104308 | 0.74 | AXL (0.57) | METAXLMERTKTYRO3 | |
| SCHEMBL3103490 | 0.74 | AXL (0.44) | METAXLMERTKTYRO3 | |
| SCHEMBL3101305 | 0.73 | MET (0.39) | METAXLMERTKTYRO3MST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3843850-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | Array BioPharma Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020047184-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. (US) | 2020-03-05 | — | — | WO | disclosed |