Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 5/20 | 0.53 |
| ▸ | MERTK | Q12866 | 5/20 | 0.53 |
| ▸ | MET | P08581 | 6/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18580740 | 0.91 | AXL (0.51) | RPS6KB1PDPK1AXLMERTKMET | |
| SCHEMBL18616235 | 0.81 | PDPK1 (0.48) | RPS6KB1PDPK1METJAK2JAK3 | |
| SCHEMBL18580289 | 0.76 | MERTK (0.72) | AXLMERTKMET | |
| SCHEMBL663299 | 0.71 | RPS6KB1 (1.00) | RPS6KB1PDPK1 | |
| SCHEMBL18611803 | 0.71 | IKBKE (0.62) | AXLMERTKMETIKBKETBK1 | |
| SCHEMBL30108229 | 0.71 | IKBKE (0.62) | AXLMERTKMETIKBKETBK1 | |
| SCHEMBL18580676 | 0.71 | MET (0.46) | AXLMERTKMETIKBKETBK1 | |
| SCHEMBL18615746 | 0.71 | RPS6KB1 (0.48) | RPS6KB1 | |
| SCHEMBL18580544 | 0.69 | AXL (1.00) | AXLMERTKMET | |
| SCHEMBL18580541 | 0.69 | AXL (1.00) | AXLMERTKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |