Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 10/20 | 0.60 |
| ▸ | MERTK | Q12866 | 10/20 | 0.60 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.53 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.53 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18616319 | 0.94 | MERTK (0.58) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL24838113 | 0.94 | MERTK (0.58) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616320 | 0.90 | AXL (0.60) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616322 | 0.89 | AXL (0.55) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616643 | 0.88 | AXL (0.66) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616317 | 0.87 | ACVR1 (0.56) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL28701689 | 0.87 | AXL (0.50) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18615840 | 0.85 | MERTK (0.58) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18617176 | 0.83 | MERTK (0.57) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18617188 | 0.82 | AXL (0.61) | AXLMERTKBMPR1BBMPR1ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |