Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 12/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21779580 | 1.00 | FOLH1 (0.48) | FOLH1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3622408 | 0.90 | HAO1 (0.43) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL11307892 | 0.90 | HAO1 (0.43) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4657392 | 0.87 | HAO1 (0.39) | FOLH1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL18151865 | 0.85 | FOLH1 (0.57) | FOLH1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL18151525 | 0.85 | FOLH1 (0.57) | FOLH1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL30293939 | 0.85 | FOLH1 (0.57) | FOLH1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL11592376 | 0.85 | FOLH1 (0.57) | FOLH1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL10384055 | 0.85 | FOLH1 (0.57) | FOLH1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL18151528 | 0.85 | FOLH1 (0.57) | FOLH1HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976076-B1 | TRAIL ENHANCERS FOR THE SELECTIVE KILLING OF CANCER CELLS | SCRIPPS RESEARCH INST (US) | 2020-03-04 | — | — | EP | disclosed |