SCHEMBL2177983

SCHEMBL2177983

Cn1cncc1-c1c(C(N)c2ccc(Cl)cc2)ccc2c1c(-c1cccc(Cl)c1)nc1nnnn12

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FNTA P49354 12/20 0.54
FNTB P49356 12/20 0.54
PGGT1B P53609 4/20 0.54
IDO1 P14902 2/20 0.41
CHEK1 O14757 1/20 0.31
LIMK1 P53667 1/20 0.31
MAPK14 Q16539 1/20 0.31
CLK4 Q9HAZ1 1/20 0.31
KCNH2 Q12809 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7644048 0.91 FNTA (0.52) FNTAFNTBPGGT1BIDO1CHEK1
SCHEMBL7091902 0.86 FNTA (0.54) FNTAFNTBPGGT1BIDO1CHEK1
SCHEMBL7092843 0.80 FNTA (0.53) FNTAFNTBPGGT1BIDO1CHEK1
SCHEMBL6556841 0.79 FNTA (0.52) FNTAFNTBPGGT1BIDO1
SCHEMBL7167060 0.77 FNTA (0.47) FNTAFNTBPGGT1BIDO1
SCHEMBL5016825 0.72 FNTA (0.61) FNTAFNTBPGGT1BIDO1
SCHEMBL7169683 0.72 FNTA (0.40) FNTAFNTBPGGT1B
SCHEMBL5543925 0.72 FNTA (0.60) FNTAFNTBPGGT1BIDO1
SCHEMBL6554448 0.70 FNTA (0.41) FNTAFNTBPGGT1BIDO1KCNH2
SCHEMBL7854629 0.70 FNTA (0.54) FNTAFNTBPGGT1BCHEK1LIMK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4725940-B2 2011-07-13 JP claimed
EP-1140935-A2 1,2-ANNELATED QUINOLINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2001-10-10 EP claimed
WO-2000039082-A2 1,2-ANNELATED QUINOLINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2000-07-06 WO claimed
EP-1339407-A1 FARNESYL PROTEIN TRANSFERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE JANSSEN PHARMACEUTICA N.V. (BE) 2003-09-03 EP disclosed
EP-1296984-A1 FARNESYL TRANSFERASE INHIBITING 1,2-ANNELATED QUINOLINE ENANTIOMER JANSSEN PHARMACEUTICA N.V. (BE) 2003-04-02 EP disclosed
EP-1267929-A2 FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS WITH AN HER2 ANTIBODY JANSSEN PHARMACEUTICA N.V. (BE) 2003-01-02 EP disclosed
EP-1267872-A2 FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS WITH ANTI-TUMOR ANTHRACYCLINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2003-01-02 EP disclosed
EP-1261356-A2 FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS WITH PLATINUM COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 2002-12-04 EP disclosed
WO-2002043733-A1 FARNESYL PROTEIN TRANSFERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE JANSSEN PHARMACEUTICA N.V. (BE) 2002-06-06 WO disclosed
WO-2001098302-A1 FARNESYL TRANSFERASE INHIBITING 1,2-ANNELATED QUINOLINE ENANTIOMER JANSSEN PHARMACEUTICA N.V. (BE) 2001-12-27 WO disclosed
WO-2001064246-A2 FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS WITH AN HER2 ANTIBODY JANSSEN PHARMACEUTICA N.V. (BE) 2001-09-07 WO disclosed
WO-2001064226-A2 FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS WITH PLATINUM COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 2001-09-07 WO disclosed
WO-2001064197-A2 FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS WITH ANTI-TUMOR ANTHRACYCLINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2001-09-07 WO disclosed