Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RB1 | P06400 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10212614 | 0.88 | GRM5 (0.62) | GRM5L3MBTL1KDM5AKMT2AMEN1 | |
| SCHEMBL20147585 | 0.87 | KMT2A (0.61) | GRM5L3MBTL1KDM5AKMT2AMEN1 | |
| SCHEMBL1116603 | 0.79 | GRM5 (0.77) | GRM5L3MBTL1KMT2AMEN1HDAC1 | |
| SCHEMBL13847098 | 0.77 | KMT2A (0.65) | GRM5L3MBTL1KMT2AMEN1CCR3 | |
| SCHEMBL29973192 | 0.77 | KMT2A (0.65) | GRM5L3MBTL1KMT2AMEN1CCR3 | |
| SCHEMBL13294374 | 0.76 | GRM5 (0.81) | GRM5L3MBTL1KMT2AMEN1 | |
| SCHEMBL3462086 | 0.76 | GRM5 (0.71) | GRM5L3MBTL1KMT2AMEN1HDAC1 | |
| SCHEMBL30804734 | 0.76 | GRM5 (0.67) | GRM5L3MBTL1KMT2AMEN1HDAC1 | |
| SCHEMBL1366139 | 0.75 | HPGDS (0.51) | KDM5A | |
| SCHEMBL21779907 | 0.75 | GAA (0.50) | GRM5KDM5AKMT2AMEN1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3616753-A1 | COMPOUNDS FOR MODULATING ADENOSINE A2B RECEPTOR AND ADENOSINE A2A RECEPTOR | Corvus Pharmaceuticals, Inc. (US) | 2020-03-04 | — | — | EP | disclosed |