SCHEMBL21780050

SCHEMBL21780050

CC(C)(C)OC(=O)NC/C(=C/F)COc1ccc(C(=O)Nc2ccccc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 2/20 0.49
MAOB P27338 1/20 0.49
KMT2A Q03164 8/20 0.47
NPC1 O15118 5/20 0.47
MEN1 O00255 7/20 0.46
TDP1 Q9NUW8 1/20 0.46
HDAC1 Q13547 1/20 0.46
NAMPT P43490 2/20 0.45
RAB9A P51151 3/20 0.45
RXFP1 Q9HBX9 1/20 0.45
CHRNB2 P17787 1/20 0.44
CHRNB4 P30926 1/20 0.44
CHRNA3 P32297 1/20 0.44
CHRNA7 P36544 1/20 0.44
CHRNA4 P43681 1/20 0.44
CHRNA10 Q9GZZ6 1/20 0.44
CHRNA9 Q9UGM1 1/20 0.44
ALDH1A1 P00352 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
MAPK1 P28482 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21780053 0.91 AOC3 (0.48) AOC3MAOBKMT2ANPC1MEN1
SCHEMBL21768045 0.86 ALDH1A1 (0.49) AOC3MAOBKMT2ANPC1MEN1
SCHEMBL21768044 0.86 ALDH1A1 (0.49) AOC3MAOBKMT2ANPC1MEN1
SCHEMBL23718599 0.86 AOC3 (0.50) AOC3MAOBMAPK1
SCHEMBL21768043 0.86 AOC3 (0.50) AOC3MAOBMAPK1
SCHEMBL21780054 0.86 AOC3 (0.50) AOC3MAOBMAPK1
SCHEMBL21780044 0.83 AOC3 (0.49) AOC3MAOBNPC1RAB9AALDH1A1
SCHEMBL21768135 0.83 AOC3 (0.49) AOC3MAOBNPC1RAB9AALDH1A1
SCHEMBL23718635 0.83 AOC3 (0.49) AOC3MAOBNPC1RAB9AALDH1A1
SCHEMBL23718801 0.82 KMT2A (0.43) AOC3MAOBKMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3617186-A1 FLUOROALLYLAMINE DERIVATIVE AND USE THEREOF Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2020-03-04 EP disclosed