SCHEMBL21780085

SCHEMBL21780085

CC(C)(C)OC(=O)NC/C(=C/F)COc1ccc(C(=O)N2CCc3cc(C(F)(F)F)ccc3C2)cc1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA7 P43166 1/20 0.40
CA9 Q16790 1/20 0.40
CA14 Q9ULX7 1/20 0.40
NAMPT P43490 3/20 0.39
PRMT5 O14744 4/20 0.38
WDR77 Q9BQA1 4/20 0.38
AOC3 Q16853 3/20 0.38
MAOB P27338 1/20 0.38
ESR2 Q92731 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
PHGDH O43175 1/20 0.38
ESR1 P03372 1/20 0.38
LMNA P02545 1/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
PDE4B Q07343 1/20 0.37
PDE4D Q08499 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21780130 0.88 KMT2A (0.47) NAMPTPRMT5WDR77L3MBTL1LMNA
SCHEMBL21780087 0.85 AOC3 (0.52) CA1CA2CA7CA9CA14
Trifluoroacetic Acid SCHEMBL21768076 0.82 AOC3 (0.51) CA1CA2CA7CA9CA14
SCHEMBL21780097 0.78 NPC1 (0.45) PRMT5WDR77LMNAHTTSMN1; SMN2
SCHEMBL22725877 0.77 AOC3 (0.65) AOC3
SCHEMBL22725873 0.77 AOC3 (0.65) AOC3
SCHEMBL23718599 0.74 AOC3 (0.50) CA1CA2CA9AOC3MAOB
SCHEMBL21780054 0.74 AOC3 (0.50) CA1CA2CA9AOC3MAOB
SCHEMBL21768043 0.74 AOC3 (0.50) CA1CA2CA9AOC3MAOB
SCHEMBL23718635 0.74 AOC3 (0.49) CA1CA2CA9AOC3MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3617186-A1 FLUOROALLYLAMINE DERIVATIVE AND USE THEREOF Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2020-03-04 EP disclosed