Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26650258 | 0.77 | CTSK (0.43) | CTSKBTKCA1CA2HSD11B1 | |
| SCHEMBL8272525 | 0.76 | SSTR4 (0.39) | CA1CA2SSTR4GAAEPHX2 | |
| SCHEMBL12814322 | 0.76 | CTSK (0.54) | CTSKBTKCA1CA2NFKB1 | |
| SCHEMBL19021203 | 0.75 | BTK (0.49) | CTSKBTKCA1CA2NFKB1 | |
| SCHEMBL14801762 | 0.75 | BTK (0.49) | CTSKBTKCA1CA2NFKB1 | |
| SCHEMBL17409347 | 0.75 | BTK (0.49) | CTSKBTKCA1CA2NFKB1 | |
| SCHEMBL26514289 | 0.75 | CTSK (0.44) | CTSKBTKCA1CA2NFKB1 | |
| SCHEMBL7554917 | 0.75 | CTSK (0.41) | CTSKBTKCA1CA2NFKB1 | |
| SCHEMBL23731495 | 0.74 | CTSK (0.55) | CTSKBTKCA1CA2NFKB1 | |
| SCHEMBL29042564 | 0.74 | CTSK (0.49) | CTSKBTKCA1CA2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |