Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.60 |
| ▸ | SCN1A | P35498 | 1/20 | 0.58 |
| ▸ | SCN4A | P35499 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.58 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.58 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.58 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.58 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.58 |
| ▸ | TNIK | Q9UKE5 | 10/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14480854 | 0.92 | ROCK2 (0.70) | ROCK2ROCK1SCN1ASCN4AKCNH2 | |
| SCHEMBL14480714 | 0.86 | ROCK2 (0.69) | ROCK2ROCK1SCN1ASCN4AKCNH2 | |
| SCHEMBL14480884 | 0.84 | SCN1A (0.73) | ROCK2ROCK1SCN1ASCN4AKCNH2 | |
| SCHEMBL14480851 | 0.83 | ROCK2 (0.68) | ROCK2ROCK1SCN1ASCN4AKCNH2 | |
| SCHEMBL14480581 | 0.82 | SCN1A (0.85) | ROCK2ROCK1SCN1ASCN4AKCNH2 | |
| SCHEMBL14480891 | 0.78 | KCNH2 (0.77) | ROCK2ROCK1SCN1ASCN4AKCNH2 | |
| SCHEMBL14480749 | 0.78 | SCN1A (0.71) | ROCK2ROCK1SCN1ASCN4AKCNH2 | |
| SCHEMBL14480701 | 0.77 | SCN1A (0.68) | ROCK2ROCK1SCN1ASCN4AKCNH2 | |
| SCHEMBL14480678 | 0.77 | ROCK2 (0.67) | ROCK2ROCK1SCN1ASCN4AKCNH2 | |
| SCHEMBL17014542 | 0.76 | SCN1A (0.86) | ROCK2ROCK1SCN1ASCN4AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |