Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14480767 | 1.00 | HRH3 (0.37) | HRH3AXLROCK2ROCK1SCN1A | |
| SCHEMBL14480898 | 1.00 | HRH3 (0.37) | HRH3AXLROCK2ROCK1SCN1A | |
| SCHEMBL14480503 | 0.90 | HRH3 (0.37) | HRH3AXLROCK2ROCK1SCN1A | |
| SCHEMBL21780490 | 0.90 | HRH3 (0.37) | HRH3AXLROCK2ROCK1SCN1A | |
| SCHEMBL14480765 | 0.90 | HRH3 (0.37) | HRH3AXLROCK2ROCK1SCN1A | |
| SCHEMBL21780498 | 0.88 | HRH3 (0.36) | HRH3AXLROCK2ROCK1SCN1A | |
| SCHEMBL14480747 | 0.88 | HRH3 (0.36) | HRH3AXLROCK2ROCK1SCN1A | |
| SCHEMBL14480859 | 0.88 | HRH3 (0.36) | HRH3AXLROCK2ROCK1SCN1A | |
| SCHEMBL21780418 | 0.88 | HTR2A (0.41) | HRH3AXLROCK2ROCK1SCN1A | |
| SCHEMBL14481168 | 0.85 | KCNH2 (0.49) | HRH3ROCK2ROCK1SCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |