Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.37 |
| ▸ | POLQ | O75417 | 9/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19145665 | 0.77 | AR (0.38) | AR | |
| SCHEMBL21516362 | 0.74 | CRHR1 (0.48) | ARPOLQ | |
| SCHEMBL20388971 | 0.73 | NOTUM (0.39) | AR | |
| SCHEMBL12834802 | 0.71 | FFAR4 (0.40) | ARIDO1EPHX2 | |
| SCHEMBL4416164 | 0.71 | POLQ (0.51) | POLQIDO1 | |
| SCHEMBL10256179 | 0.71 | SMN1; SMN2 (0.39) | ARPOLQIDO1EPHX2 | |
| SCHEMBL8417818 | 0.71 | IDO1 (0.59) | POLQIDO1SLC6A4SLC6A2EPHX2 | |
| SCHEMBL16770736 | 0.69 | KDM1A (0.42) | ARPOLQIDO1SLC6A4EPHX2 | |
| SCHEMBL19304121 | 0.69 | HSD17B3 (0.41) | ARPOLQIDO1EPHX2 | |
| SCHEMBL805479 | 0.69 | POLQ (0.52) | POLQSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3722284-A1 | 3-((HETERO-)ARYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2020-10-14 | — | — | EP | disclosed |
| EP-3402781-B1 | 3-((HETERO-)ARYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2020-03-04 | — | — | EP | disclosed |