Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13548 | 0.89 | KMO (0.49) | KMOEGFRGLSCACNA1HHTR2A | |
| SCHEMBL539125 | 0.84 | KMO (0.48) | KMOEGFRGLSSLC9A1HTR2A | |
| SCHEMBL2444717 | 0.83 | KMO (0.50) | KMOEGFRGLSHTR2AHTR2C | |
| SCHEMBL30928551 | 0.82 | KMO (0.44) | KMOEGFRGLSCACNA1HHTR2A | |
| SCHEMBL13528 | 0.82 | KMO (0.44) | KMOEGFRGLSCACNA1HHTR2A | |
| SCHEMBL109465 | 0.81 | KMO (0.50) | KMOEGFRGLSHTR2AHTR2C | |
| SCHEMBL21183580 | 0.80 | KMO (0.49) | KMOEGFRGLSHTR2AHTR2C | |
| SCHEMBL29804486 | 0.80 | KMO (0.52) | KMOEGFRGLSHTR2AHTR2C | |
| SCHEMBL15447295 | 0.80 | KMO (0.52) | KMOEGFRGLSHTR2AHTR2C | |
| SCHEMBL27799511 | 0.79 | KMO (0.50) | KMOEGFRGLSHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233828-B1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2020-03-04 | — | — | EP | disclosed |