Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1186911 | 0.93 | MEN1 (0.52) | MEN1KMT2ALMNASMN1; SMN2RAB9A | |
| SCHEMBL818344 | 0.88 | TNK2 (0.40) | MEN1KMT2ALMNASMN1; SMN2RAB9A | |
| SCHEMBL11767308 | 0.87 | ELANE (0.52) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL15067474 | 0.86 | MEN1 (0.47) | MEN1KMT2ALMNASMN1; SMN2RAB9A | |
| SCHEMBL5725421 | 0.86 | LSS (0.49) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL15088638 | 0.85 | KMT2A (0.45) | MEN1KMT2ALMNASMN1; SMN2RAB9A | |
| SCHEMBL6203607 | 0.85 | NPC1 (0.47) | MEN1KMT2ALMNASMN1; SMN2RAB9A | |
| SCHEMBL2281345 | 0.84 | SMN1; SMN2 (0.60) | MEN1KMT2ALMNASMN1; SMN2RAB9A | |
| SCHEMBL5427612 | 0.83 | MEN1 (0.44) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL225085 | 0.82 | KMT2A (0.65) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233828-B1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2020-03-04 | — | — | EP | disclosed |