Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179351 | 0.84 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4ETSHRHSD17B10 | |
| SCHEMBL2179347 | 0.84 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4ETSHRHSD17B10 | |
| SCHEMBL12408656 | 0.81 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4ETSHRHSD17B10 | |
| SCHEMBL2177333 | 0.74 | KDM4E (0.36) | ALDH1A1KDM4ESMN1; SMN2MAPTUSP2 | |
| SCHEMBL2177340 | 0.74 | KDM4E (0.36) | ALDH1A1KDM4ESMN1; SMN2MAPTUSP2 | |
| SCHEMBL2179117 | 0.73 | PDE10A (0.73) | ALDH1A1HPGDKDM4ETSHRHSD17B10 | |
| SCHEMBL2179110 | 0.73 | PDE10A (0.73) | ALDH1A1HPGDKDM4ETSHRHSD17B10 | |
| SCHEMBL12408669 | 0.72 | PDE10A (0.57) | ALDH1A1HPGDKDM4ETSHRHSD17B10 | |
| SCHEMBL2187652 | 0.72 | ALDH1A1 (0.38) | ALDH1A1HPGDKDM4EHSD17B10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2179746 | 0.72 | PDE10A (0.72) | ALDH1A1HPGDKDM4ETSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130072477-A1 | TREATMENT OF PARKINSON'S DISEASE AND ENHANCEMENT OF DOPAMINE SIGNAL USING PDE 10 INHIBITOR | MITSUBISHI TANABE PHARMA COPORATION (JP) | 2013-03-21 | — | — | US | disclosed |
| EP-2342191-B1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-03-20 | — | — | EP | disclosed |
| US-8338420-B1 | Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-12-25 | — | — | US | disclosed |
| EP-2342191-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | Mitsubishi Tanabe Pharma Corporation (JP) | 2011-07-13 | — | — | EP | disclosed |
| US-20110166135-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-07-07 | — | — | US | disclosed |
| WO-2010030027-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166135-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | PDE10A, PDE3A, PDE3B | ALDH1A1 1520/4885HPGD 679/4885KDM4E 397/4885 |
| US-20130072477-A1 | TREATMENT OF PARKINSON'S DISEASE AND ENHANCEMENT OF DOPAMINE SIGNAL USING PDE 10 INHIBITOR | PDE3A, PDE2A, PDE5A | ALDH1A1 1085/4885HPGD 260/4885KDM4E 1887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.