Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191532 | 1.00 | KIT (0.48) | KITGPR119MAP4K4CNR1CNR2 | |
| SCHEMBL191269 | 0.85 | KIT (0.45) | KITGPR119MAP4K4CNR1CNR2 | |
| SCHEMBL15451607 | 0.83 | ACHE (0.45) | MAP4K4CNR2PDE10AALDH1A1 | |
| SCHEMBL2797835 | 0.79 | KIT (0.48) | KITGPR119MAP4K4CNR1CNR2 | |
| SCHEMBL2797832 | 0.79 | KIT (0.48) | KITGPR119MAP4K4CNR1CNR2 | |
| SCHEMBL192136 | 0.79 | AKT1 (0.55) | — | |
| SCHEMBL190926 | 0.79 | AKT1 (0.55) | — | |
| SCHEMBL29391120 | 0.79 | AKT1 (0.55) | — | |
| SCHEMBL192707 | 0.79 | AKT1 (0.55) | — | |
| SCHEMBL192135 | 0.79 | AKT1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3617330-A1 | BIOMARKERS FOR PREDICTING SENSITIVITY TO CANCER TREATMENTS | Genentech, Inc. (US) | 2020-03-04 | — | — | EP | disclosed |