Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 10/20 | 0.38 |
| ▸ | SCN1A | P35498 | 8/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.38 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.32 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783448 | 0.73 | SCN8A (0.42) | SCN8ASCN1ASCN5ASCN1BMEN1 | |
| SCHEMBL10147870 | 0.71 | SCN8A (0.36) | SCN8A | |
| SCHEMBL20256726 | 0.70 | SCN8A (0.43) | SCN8ASCN1ASCN5ASCN1B | |
| SCHEMBL21783517 | 0.70 | SCN8A (0.69) | SCN8ASCN1ASCN5ASCN1B | |
| SCHEMBL30047171 | 0.70 | SCN8A (0.69) | SCN8ASCN1ASCN5ASCN1B | |
| SCHEMBL16120733 | 0.69 | SCN9A (0.34) | SCN8ASCN1ASCN5ASCN1B | |
| SCHEMBL21783341 | 0.69 | SCN8A (0.60) | SCN8ASCN1ASCN5ASCN1B | |
| SCHEMBL30046287 | 0.69 | SCN8A (0.60) | SCN8ASCN1ASCN5ASCN1B | |
| SCHEMBL19627627 | 0.69 | SCN8A (0.46) | SCN8ASCN1ASCN5AMEN1KMT2A | |
| SCHEMBL20256416 | 0.67 | SCN8A (0.42) | SCN8ASCN1ASCN5ASCN1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047323-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2020-03-05 | — | — | WO | disclosed |