Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 7/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 7/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.34 |
| ▸ | LCK | P06239 | 3/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783433 | 0.86 | SCN1A (0.37) | SCN1ASCN8ASCN5ACYP17A1BRAF | |
| SCHEMBL21783488 | 0.81 | LCK (0.36) | SCN1ASCN8ASCN5ALCKCYP17A1 | |
| SCHEMBL21783417 | 0.80 | CYP17A1 (0.35) | SCN1ASCN8ASCN5ACYP17A1BRAF | |
| SCHEMBL30046014 | 0.79 | SCN1A (0.56) | SCN1ASCN8ASCN5A | |
| SCHEMBL21783388 | 0.79 | SCN1A (0.56) | SCN1ASCN8ASCN5A | |
| SCHEMBL21783542 | 0.77 | CYP17A1 (0.39) | LCKCYP17A1BRAFSYK | |
| SCHEMBL21783431 | 0.73 | SCN1A (0.32) | SCN1ASCN8ASCN5A | |
| SCHEMBL165039 | 0.72 | ATR (0.40) | LCKCYP17A1PI4KBMETAP1 | |
| SCHEMBL23148155 | 0.71 | CYP17A1 (0.41) | LCKCYP17A1BRAF | |
| SCHEMBL21783402 | 0.71 | LCK (0.43) | LCKCYP17A1BRAFSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047323-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2020-03-05 | — | — | WO | disclosed |