Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 2/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783389 | 0.86 | SCN1A (0.35) | SCN1ASCN5ASCN8ABRAFCYP17A1 | |
| SCHEMBL21783430 | 0.81 | SCN1A (0.55) | SCN1ASCN5ASCN8A | |
| SCHEMBL21783561 | 0.79 | BRAF (0.40) | BRAFDGAT1CYP17A1METAP1MAPKAPK2 | |
| SCHEMBL21783472 | 0.75 | SCN1A (0.31) | SCN1ASCN5ASCN8A | |
| SCHEMBL21783471 | 0.74 | BRAF (0.41) | BRAFDGAT1CYP17A1MAPKAPK2 | |
| SCHEMBL30045766 | 0.74 | BRAF (0.41) | BRAFDGAT1CYP17A1MAPKAPK2 | |
| SCHEMBL30046068 | 0.73 | NPSR1 (0.42) | BRAF | |
| SCHEMBL21783435 | 0.73 | NPSR1 (0.42) | BRAF | |
| SCHEMBL21783559 | 0.70 | BRAF (0.39) | SCN1ASCN5ASCN8ABRAFDGAT1 | |
| SCHEMBL30045577 | 0.70 | BRAF (0.39) | SCN1ASCN5ASCN8ABRAFDGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047323-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2020-03-05 | — | — | WO | disclosed |