Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783377 | 0.85 | MEN1 (0.37) | KMT2AMEN1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL21783444 | 0.84 | KMT2A (0.37) | KMT2AMEN1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL20256741 | 0.83 | KMT2A (0.35) | KMT2AMEN1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL19634018 | 0.82 | MEN1 (0.39) | KMT2AMEN1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL21794007 | 0.81 | GAA (0.42) | KMT2AMEN1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL21783480 | 0.80 | SCN8A (0.51) | CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL19633951 | 0.80 | KMT2A (0.36) | KMT2AMEN1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL19634258 | 0.80 | HTR2A (0.38) | KMT2AMEN1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL19634006 | 0.79 | DHFR (0.36) | KMT2AMEN1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL19634254 | 0.79 | KMT2A (0.37) | KMT2AMEN1ALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047323-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2020-03-05 | — | — | WO | disclosed |