Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 12/20 | 0.62 |
| ▸ | SCN5A | Q14524 | 12/20 | 0.62 |
| ▸ | SCN8A | Q9UQD0 | 12/20 | 0.62 |
| ▸ | CD38 | P28907 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783400 | 0.77 | SCN1A (1.00) | SCN1ASCN5ASCN8AALDH1A1 | |
| SCHEMBL21793973 | 0.73 | SCN1A (0.32) | SCN1ASCN5ASCN8A | |
| SCHEMBL21793928 | 0.70 | MEN1 (0.36) | SCN1ASCN5ASCN8AMEN1ALDH1A1 | |
| SCHEMBL21783452 | 0.69 | SCN1A (0.53) | SCN1ASCN5ASCN8AMEN1ALDH1A1 | |
| SCHEMBL31018018 | 0.68 | SCN1A (0.78) | SCN1ASCN5ASCN8AALDH1A1 | |
| SCHEMBL21783449 | 0.68 | SCN1A (0.78) | SCN1ASCN5ASCN8AALDH1A1 | |
| SCHEMBL20256712 | 0.62 | SCN5A (0.47) | SCN1ASCN5ASCN8AMEN1ALDH1A1 | |
| SCHEMBL23526016 | 0.58 | EED (0.40) | SCN1ASCN5ASCN8AMEN1ALDH1A1 | |
| SCHEMBL29945862 | 0.58 | EED (0.40) | SCN1ASCN5ASCN8AMEN1ALDH1A1 | |
| SCHEMBL28616526 | 0.55 | EED (0.39) | MEN1ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047323-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2020-03-05 | — | — | WO | disclosed |