Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29365972 | 1.00 | GPR119 (0.44) | GPR119NR1H2JAK2JAK1KDM4E | |
| SCHEMBL21783667 | 1.00 | GPR119 (0.44) | GPR119NR1H2JAK2JAK1KDM4E | |
| SCHEMBL1329227 | 0.92 | GPR119 (0.48) | GPR119KDM4EPKMHPGDALDH1A1 | |
| SCHEMBL16545031 | 0.89 | NR1H2 (0.49) | GPR119NR1H2JAK2JAK1HPGD | |
| SCHEMBL25835179 | 0.89 | GPR119 (0.36) | GPR119NR1H2JAK2JAK1KDM4E | |
| SCHEMBL34474175 | 0.88 | GPR119 (0.46) | GPR119NR1H2JAK2JAK1KDM4E | |
| SCHEMBL31209154 | 0.88 | GPR119 (0.46) | GPR119NR1H2JAK2JAK1KDM4E | |
| SCHEMBL3561605 | 0.88 | GPR119 (0.46) | GPR119NR1H2JAK2JAK1KDM4E | |
| SCHEMBL25314409 | 0.83 | NR1H2 (0.48) | GPR119NR1H2KDM4EPKMUSP30 | |
| SCHEMBL25311767 | 0.83 | NR1H2 (0.48) | GPR119NR1H2KDM4EPKMUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081154-A1 | INHIBITORS OF ανβ6 INTEGRIN | MORPHIC THERAPEUTIC, INC. (US) | 2020-04-23 | — | — | WO | disclosed |
| WO-2020047208-A1 | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN | MORPHIC THERAPEUTIC, INC. (US) | 2020-03-05 | — | — | WO | disclosed |