Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 11/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19682735 | 0.85 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4OPRL1 | |
| SCHEMBL31071936 | 0.85 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4OPRL1 | |
| SCHEMBL21767543 | 0.76 | BACE1 (0.33) | — | |
| SCHEMBL31071957 | 0.76 | BACE1 (0.33) | — | |
| SCHEMBL21784957 | 0.76 | ESR2 (0.37) | CHRNB2CHRNB4CHRNA3CHRNA4OPRL1 | |
| SCHEMBL27797108 | 0.71 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4HTR1A | |
| SCHEMBL24215291 | 0.69 | QPCT (0.36) | CHRNB2CHRNA4OPRL1KDM1A | |
| SCHEMBL1782611 | 0.69 | TP53 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4HTR2C | |
| SCHEMBL26615751 | 0.69 | HDAC1 (0.32) | — | |
| SCHEMBL21767694 | 0.68 | OPRL1 (0.33) | OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047239-A1 | INHIBITING αV β6 INTEGRIN | MORPHIC THERAPEUTIC, INC. (US) | 2020-03-05 | — | — | WO | disclosed |