Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.48 |
| ▸ | AXL | P30530 | 5/20 | 0.48 |
| ▸ | KIT | P10721 | 4/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 6/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | MST1R | Q04912 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891253 | 0.93 | KDR (0.55) | KDRPDGFRAAXLKITFGFR2 | |
| SCHEMBL1893463 | 0.91 | PDGFRA (0.52) | KDRPDGFRAAXLKITFGFR2 | |
| SCHEMBL1893177 | 0.86 | MET (0.53) | KDRPDGFRAAXLKITFGFR2 | |
| SCHEMBL12673475 | 0.86 | KDR (0.51) | KDRPDGFRAAXLKITFGFR2 | |
| SCHEMBL1894997 | 0.85 | KDR (0.57) | KDRPDGFRAAXLKITFGFR2 | |
| SCHEMBL1897216 | 0.85 | KDR (0.59) | KDRPDGFRAAXLKITFGFR2 | |
| SCHEMBL12503732 | 0.85 | KDR (0.58) | KDRPDGFRAAXLKITFGFR2 | |
| SCHEMBL2178218 | 0.83 | KDR (0.63) | KDRPDGFRAAXLKITFGFR2 | |
| SCHEMBL12503701 | 0.83 | KDR (0.49) | KDRPDGFRAAXLKITFGFR2 | |
| SCHEMBL1892065 | 0.83 | KDR (0.69) | KDRPDGFRAAXLKITFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973160-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-07-05 | — | — | US | disclosed |