Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2180234 | 0.83 | KMO (0.58) | KMOMAPTCYP2C19SMN1; SMN2KMT2A | |
| SCHEMBL2350284 | 0.80 | CYP2C19 (0.68) | MAPTCYP2C19SMN1; SMN2LMNACYP2C9 | |
| SCHEMBL2177837 | 0.77 | CYP2C19 (0.68) | MAPTCYP2C19SMN1; SMN2LMNACYP2C9 | |
| SCHEMBL14758742 | 0.76 | KMO (1.00) | KMOCYP2C19CYP2C9TSHRBACE1 | |
| SCHEMBL12684797 | 0.76 | MAPT (1.00) | MAPTCYP2C19SMN1; SMN2KMT2ALMNA | |
| SCHEMBL4666194 | 0.76 | TP53 (0.61) | MAPTCYP2C19KMT2ACYP2C9TSHR | |
| SCHEMBL4665854 | 0.75 | BACE1 (0.60) | KMOMAPTCYP2C19KMT2ALMNA | |
| SCHEMBL4665753 | 0.75 | BACE1 (0.55) | KMOMAPTCYP2C19SMN1; SMN2LMNA | |
| Sulfamonomethoxine SCHEMBL93784 | 0.74 | CYP2C19 (1.00) | MAPTCYP2C19SMN1; SMN2KMT2ALMNA | |
| SCHEMBL1136466 | 0.74 | CYP2C19 (0.64) | MAPTCYP2C19SMN1; SMN2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-01-24 | — | — | US | disclosed |
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-01-24 | — | — | US | disclosed |
| WO-2011082400-A2 | MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011082400-A2 | MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | CD274, PDCD1LG2, PDCD1 | KMO 741/4885MAPT 4352/4885CYP2C19 2798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.