Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13003 | 0.92 | KDM4E (0.51) | KDM4EALDH1A1TAAR1LMNAMAPT | |
| SCHEMBL12449635 | 0.92 | KDM4E (0.51) | KDM4EALDH1A1TAAR1LMNAMAPT | |
| SCHEMBL12449637 | 0.92 | KDM4E (0.51) | KDM4EALDH1A1TAAR1LMNAMAPT | |
| SCHEMBL1430963 | 0.84 | — | — | |
| SCHEMBL6774992 | 0.84 | — | — | |
| SCHEMBL12717823 | 0.84 | — | — | |
| SCHEMBL12666 | 0.82 | KDM4E (0.49) | KDM4EL3MBTL1ALDH1A1TAAR1LMNA | |
| SCHEMBL11907 | 0.82 | KDM4E (0.49) | KDM4EL3MBTL1ALDH1A1TAAR1LMNA | |
| SCHEMBL2114689 | 0.81 | KDM4E (0.49) | KDM4EALDH1A1HRH3 | |
| SCHEMBL738472 | 0.81 | KDM4E (0.49) | KDM4EALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047192-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-03-05 | — | — | WO | disclosed |