Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 2/20 | 0.39 |
| ▸ | SKP1 | P63208 | 2/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29697503 | 0.94 | KIT (0.49) | KITMAP4K4CNR1CNR2CKS1B | |
| SCHEMBL30333389 | 0.87 | KIT (0.49) | KITMAP4K4CNR1CNR2CKS1B | |
| SCHEMBL31029604 | 0.87 | KIT (0.49) | KITMAP4K4CNR1CNR2CKS1B | |
| SCHEMBL2796064 | 0.83 | KIT (0.49) | KITMAP4K4CNR1CNR2CKS1B | |
| SCHEMBL19616882 | 0.80 | KIT (0.48) | KITMAP4K4CNR1CNR2CKS1B | |
| SCHEMBL21243934 | 0.79 | KIT (0.48) | KITMAP4K4CNR1CNR2CKS1B | |
| SCHEMBL30547305 | 0.79 | PARP1 (0.39) | — | |
| SCHEMBL23686777 | 0.78 | JAK3 (0.37) | KITGPR119RET | |
| SCHEMBL23075010 | 0.77 | KRAS (0.48) | — | |
| SCHEMBL2572791 | 0.77 | AKT1 (0.50) | KITMAP4K4CNR1CNR2CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3844151-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2020047192-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-03-05 | — | — | WO | disclosed |