Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19771956 | 0.81 | HTT (0.35) | EGLN2KDM4EALDH1A1L3MBTL1HTT | |
| SCHEMBL24595125 | 0.80 | PTGER4 (0.41) | EGLN2KDM4EALDH1A1L3MBTL1HTT | |
| SCHEMBL29395259 | 0.79 | KDM4E (0.39) | EGLN2KDM4EALDH1A1L3MBTL1HTT | |
| SCHEMBL25238478 | 0.79 | KDM4E (0.39) | EGLN2KDM4EALDH1A1L3MBTL1HTT | |
| SCHEMBL25786530 | 0.79 | KDM4E (0.39) | EGLN2KDM4EALDH1A1L3MBTL1HTT | |
| SCHEMBL21786716 | 0.77 | KDM4E (0.38) | EGLN2KDM4EALDH1A1L3MBTL1HTT | |
| SCHEMBL1425018 | 0.76 | EGLN2 (0.37) | EGLN2KDM4EALDH1A1L3MBTL1HTT | |
| SCHEMBL20470819 | 0.74 | EGLN2 (0.40) | EGLN2KDM4EALDH1A1L3MBTL1HTT | |
| SCHEMBL30624366 | 0.71 | HTT (0.44) | EGLN2KDM4EALDH1A1L3MBTL1HTT | |
| SCHEMBL846133 | 0.71 | HTT (0.44) | EGLN2KDM4EALDH1A1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020046813-A1 | CD73 INHIBITORS | ARCUS BIOSCIENCES, INC. (US) | 2020-03-05 | — | — | WO | disclosed |