Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.63 |
| ▸ | JAK2 | O60674 | 9/20 | 0.62 |
| ▸ | JAK1 | P23458 | 9/20 | 0.62 |
| ▸ | ABL1 | P00519 | 3/20 | 0.56 |
| ▸ | BCR | P11274 | 3/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12482572 | 0.88 | JAK2 (0.62) | JAK3JAK2JAK1ABL1BCR | |
| SCHEMBL12487942 | 0.86 | JAK2 (0.60) | JAK3JAK2JAK1ABL1BCR | |
| SCHEMBL374409 | 0.83 | CD274 (0.59) | JAK3JAK2JAK1ABL1BCR | |
| SCHEMBL374117 | 0.79 | CD274 (0.57) | JAK3JAK2JAK1ABL1BCR | |
| SCHEMBL12963107 | 0.78 | GAA (0.59) | MAPTMAPK1HTT | |
| SCHEMBL2194198 | 0.78 | JAK2 (0.56) | JAK3JAK2JAK1ABL1BCR | |
| SCHEMBL374420 | 0.78 | JAK1 (0.66) | JAK3JAK2JAK1CD274TYK2 | |
| SCHEMBL28290063 | 0.77 | JAK2 (0.67) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL14660127 | 0.77 | CD274 (0.57) | JAK3JAK2JAK1ABL1BCR | |
| SCHEMBL12482797 | 0.75 | JAK2 (0.53) | JAK3JAK2JAK1CD274TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519501-A2 | SUBSTITUTED PYRIDINES AND PYRIMIDINES FOR THE PRODUCTION OF CARDIOMYOCYTE-LIKE CELLS | Technische Universität Wien (AT) | 2012-11-07 | — | — | EP | claimed |
| WO-2011079343-A2 | SUBSTITUTED PYRIDINES AND PYRIMIDINES | TECHNISCHE UNIVERSITAET WIEN (AT) | 2011-07-07 | — | — | WO | claimed |