Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.67 |
| ▸ | JAK3 | P52333 | 10/20 | 0.67 |
| ▸ | JAK1 | P23458 | 9/20 | 0.67 |
| ▸ | TYK2 | P29597 | 2/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28288635 | 0.83 | JAK2 (0.64) | JAK2JAK3JAK1TYK2PIK3CB | |
| SCHEMBL2481110 | 0.81 | STAT6 (0.61) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL28876030 | 0.79 | JAK3 (0.84) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL29813697 | 0.79 | JAK3 (0.84) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL374117 | 0.78 | CD274 (0.57) | JAK2JAK3JAK1TYK2PLK4 | |
| SCHEMBL2178686 | 0.77 | JAK3 (0.63) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL12482572 | 0.77 | JAK2 (0.62) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL12192511 | 0.76 | MAPK10 (0.54) | JAK2JAK3JAK1PLK4 | |
| SCHEMBL12487942 | 0.75 | JAK2 (0.60) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL374409 | 0.75 | CD274 (0.59) | JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109678803-A | A kind of preparation and application of novel 4,6- disubstituted amido miazines jak kinase inhibitor | 中国药科大学 | 2019-04-26 | — | — | CN | disclosed |