SCHEMBL21788652

SCHEMBL21788652

CN1CC2(CCc3ccccc32)C1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 17/20 0.54
ALDH1A1 P00352 1/20 0.49
TP53 P04637 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
TSHR P16473 1/20 0.49
CYP2C19 P33261 1/20 0.49
EBP Q15125 1/20 0.48
HTR2A P28223 2/20 0.47
HTR2C P28335 2/20 0.47
HTR2B P41595 2/20 0.47
OPRM1 P35372 1/20 0.46
OPRL1 P41146 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12084851 0.91 SIGMAR1 (0.57) SIGMAR1TP53CYP1A2CYP3A4CYP2D6
SCHEMBL11937070 0.87 SIGMAR1 (0.57) SIGMAR1ALDH1A1TP53CYP1A2CYP3A4
SCHEMBL2743258 0.85 SIGMAR1 (0.67) SIGMAR1ALDH1A1TP53CYP1A2CYP3A4
SCHEMBL11937068 0.84 SIGMAR1 (0.51) SIGMAR1ALDH1A1TP53CYP1A2CYP3A4
SCHEMBL17339943 0.81 SIGMAR1 (0.56) SIGMAR1TP53CYP1A2CYP3A4CYP2D6
SCHEMBL11937071 0.81 SIGMAR1 (0.59) SIGMAR1TP53CYP1A2CYP3A4CYP2D6
SCHEMBL23770526 0.80 SIGMAR1 (0.47) SIGMAR1ALDH1A1TP53CYP1A2CYP3A4
SCHEMBL26990553 0.80 SIGMAR1 (0.57) SIGMAR1ALDH1A1TP53CYP1A2CYP3A4
SCHEMBL19041309 0.79 SIGMAR1 (0.58) SIGMAR1ALDH1A1TP53CYP1A2CYP3A4
SCHEMBL29860963 0.79 SIGMAR1 (0.58) SIGMAR1ALDH1A1TP53CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024010810-A2 FC CONJUGATES INCLUDING AN INHIBITOR OF CD73 AND USES THEREOF CIDARA THERAPEUTICS, INC. (US) 2024-01-11 WO disclosed
WO-2020205538-A1 CD73 INHIBITORS AND THERAPEUTIC USES THEREOF Eternity Bioscience Inc. (US) 2020-10-08 WO disclosed
WO-2020151707-A1 NOVEL SMALL MOLECULE CD73 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF 江苏恒瑞医药股份有限公司 2020-07-30 WO disclosed
WO-2020047082-A1 CD73 INHIBITORS AND THERAPEUTIC USES THEREOF Eternity Bioscience Inc. (US) 2020-03-05 WO disclosed