Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878787 | 0.81 | CAMKK2 (0.42) | CYP3A4CYP2C19CYP2D6CAMKK2CSF1R | |
| SCHEMBL1267958 | 0.69 | CYP3A4 (0.83) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL2181556 | 0.69 | CYP3A4 (0.69) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL1267844 | 0.68 | CSF1R (0.77) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL4165835 | 0.68 | CAMKK2 (0.74) | CAMKK2CSF1RKITLCKFLT1 | |
| SCHEMBL4166523 | 0.68 | CAMKK2 (0.63) | CAMKK2KITPLK4RIPK1 | |
| SCHEMBL14620861 | 0.67 | CYP3A4 (0.69) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL857477 | 0.67 | CYP3A4 (0.69) | CYP3A4CYP2C19CYP2D6CSF1RKIT | |
| SCHEMBL858795 | 0.67 | CAMKK2 (0.52) | CYP3A4CYP2C19CAMKK2PLK4RIPK1 | |
| SCHEMBL7867667 | 0.66 | CAMKK2 (0.61) | CAMKK2KITPLK4RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166174-A1 | COMPOUNDS MODULATING C-KIT AND C-FMS ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. | 2011-07-07 | — | — | US | disclosed |
| US-7846941-B2 | Compounds modulating c-kit and c-fms activity and uses therefor | PLEXXIKON, INC. (US) | 2010-12-07 | — | — | US | disclosed |
| US-20070032519-A1 | Compounds modulating c-kit and c-fms activity and uses therefor | PLEXXIKON, INC. | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166174-A1 | COMPOUNDS MODULATING C-KIT AND C-FMS ACTIVITY AND USES THEREFOR | KIT, FLT3, FLT1 | CYP3A4 3915/4885CYP2C19 3012/4885CYP2D6 4024/4885 |
| US-20070032519-A1 | Compounds modulating c-kit and c-fms activity and uses therefor | KIT, FLT3, FLT1 | CYP3A4 3915/4885CYP2C19 3012/4885CYP2D6 4024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.