SCHEMBL21794019

SCHEMBL21794019

Cc1c(OC2CCN(C(C)c3ccccc3)CC2)cnc(SNc2cscn2)c1F

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN8A Q9UQD0 20/20 0.70
SCN1A P35498 14/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19634151 0.86 SCN8A (0.70) SCN8ASCN1A
SCHEMBL21794129 0.86 SCN8A (0.70) SCN8ASCN1A
SCHEMBL19634126 0.84 SCN8A (0.68) SCN8ASCN1A
SCHEMBL21794061 0.83 SCN8A (0.70) SCN8ASCN1A
SCHEMBL21772988 0.83 SCN8A (1.00) SCN8ASCN1A
SCHEMBL21772987 0.83 SCN8A (1.00) SCN8ASCN1A
SCHEMBL19634185 0.82 SCN8A (0.70) SCN8ASCN1A
SCHEMBL19634187 0.80 SCN8A (0.70) SCN8ASCN1A
Formic Acid SCHEMBL21773043 0.80 SCN8A (0.92) SCN8ASCN1A
Formic Acid SCHEMBL21773050 0.80 SCN8A (0.92) SCN8ASCN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020047312-A1 HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS XENON PHARMACEUTICALS INC. (CA) 2020-03-05 WO disclosed