Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.60 |
| ▸ | BCL6 | P41182 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175687 | 0.86 | EGFR (0.57) | EGFRBCL6MEN1KMT2AMAPT | |
| SCHEMBL12482198 | 0.83 | EPHB4 (0.56) | EGFRMEN1KMT2AMAPTLMNA | |
| SCHEMBL12486513 | 0.79 | MEN1 (0.79) | EGFRMEN1KMT2AMAPTGAA | |
| SCHEMBL1095000 | 0.79 | EGFR (0.78) | EGFRERBB3ERBB2 | |
| SCHEMBL7863619 | 0.78 | HTT (0.59) | BCL6MEN1KMT2AMAPTLMNA | |
| SCHEMBL2226234 | 0.77 | EGFR (0.54) | EGFRMAPTLMNAEPHB4MAPK1 | |
| SCHEMBL12482428 | 0.77 | BCL6 (0.59) | EGFRBCL6MEN1KMT2AMAPT | |
| SCHEMBL7777464 | 0.76 | EGFR (0.61) | EGFRMEN1KMT2ALMNAEPHB4 | |
| SCHEMBL2175165 | 0.75 | EGFR (1.00) | EGFRMEN1KMT2AMAPTLMNA | |
| SCHEMBL12517840 | 0.74 | TNNI3K (0.82) | EGFRERBB3TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519501-A2 | SUBSTITUTED PYRIDINES AND PYRIMIDINES FOR THE PRODUCTION OF CARDIOMYOCYTE-LIKE CELLS | Technische Universität Wien (AT) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011079343-A2 | SUBSTITUTED PYRIDINES AND PYRIMIDINES | TECHNISCHE UNIVERSITAET WIEN (AT) | 2011-07-07 | — | — | WO | disclosed |