Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 3/20 | 1.00 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 1.00 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 1.00 |
| ▸ | SSTR4 | P31391 | 5/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.34 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21795280 | 1.00 | TLR9 (1.00) | TLR9TLR7TLR8SSTR4AXL | |
| SCHEMBL21776668 | 0.90 | TLR8 (0.82) | TLR9TLR7TLR8SSTR4ACKR3 | |
| SCHEMBL21776672 | 0.90 | TLR8 (0.82) | TLR9TLR7TLR8SSTR4ACKR3 | |
| SCHEMBL21795479 | 0.90 | TLR8 (0.82) | TLR9TLR7TLR8SSTR4ACKR3 | |
| SCHEMBL21776673 | 0.90 | TLR8 (0.82) | TLR9TLR7TLR8SSTR4ACKR3 | |
| SCHEMBL21795289 | 0.90 | TLR8 (0.82) | TLR9TLR7TLR8SSTR4ACKR3 | |
| SCHEMBL21795386 | 0.90 | TLR8 (0.82) | TLR9TLR7TLR8SSTR4ACKR3 | |
| SCHEMBL23943083 | 0.88 | TLR8 (0.79) | TLR9TLR7TLR8SSTR4AXL | |
| SCHEMBL21795303 | 0.88 | TLR8 (0.79) | TLR9TLR7TLR8SSTR4AXL | |
| SCHEMBL30382225 | 0.88 | TLR8 (0.79) | TLR9TLR7TLR8SSTR4AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3844159-B1 | NOVEL PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN LA ROCHE (CH) | 2023-05-03 | — | — | EP | disclosed |
| WO-2020043271-A1 | NOVEL PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-03-05 | — | — | WO | disclosed |