Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.82 |
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.82 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.82 |
| ▸ | SSTR4 | P31391 | 6/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 3/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21776673 | 1.00 | TLR8 (0.82) | TLR8TLR9TLR7SSTR4ACKR3 | |
| SCHEMBL21795289 | 1.00 | TLR8 (0.82) | TLR8TLR9TLR7SSTR4ACKR3 | |
| SCHEMBL21795479 | 1.00 | TLR8 (0.82) | TLR8TLR9TLR7SSTR4ACKR3 | |
| SCHEMBL21776668 | 1.00 | TLR8 (0.82) | TLR8TLR9TLR7SSTR4ACKR3 | |
| SCHEMBL21776672 | 1.00 | TLR8 (0.82) | TLR8TLR9TLR7SSTR4ACKR3 | |
| SCHEMBL21795281 | 0.90 | TLR9 (1.00) | TLR8TLR9TLR7SSTR4ACKR3 | |
| SCHEMBL21795280 | 0.90 | TLR9 (1.00) | TLR8TLR9TLR7SSTR4ACKR3 | |
| SCHEMBL21776662 | 0.90 | TLR8 (0.66) | TLR8TLR9TLR7SSTR4ACKR3 | |
| SCHEMBL21776660 | 0.90 | TLR8 (0.66) | TLR8TLR9TLR7SSTR4ACKR3 | |
| SCHEMBL21776659 | 0.90 | TLR8 (0.66) | TLR8TLR9TLR7SSTR4ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3844159-B1 | NOVEL PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN LA ROCHE (CH) | 2023-05-03 | — | — | EP | disclosed |
| WO-2020043271-A1 | NOVEL PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-03-05 | — | — | WO | disclosed |