Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 3/20 | 0.34 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 4/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21795374 | 0.91 | KHK (0.36) | SSTR4SSTR1HCRTR1HCRTR2RBP4 | |
| SCHEMBL21776764 | 0.83 | TLR7 (0.34) | SSTR4SSTR1HCRTR1HCRTR2JAK2 | |
| SCHEMBL21795320 | 0.82 | TLR7 (0.37) | SSTR4SSTR1RBP4TTR | |
| SCHEMBL21795318 | 0.82 | TLR7 (0.37) | SSTR4SSTR1RBP4TTR | |
| SCHEMBL21795527 | 0.82 | TLR7 (0.37) | SSTR4SSTR1RBP4TTR | |
| SCHEMBL21795524 | 0.82 | GAA (0.39) | SSTR4SSTR1JAK2JAK1 | |
| SCHEMBL21795472 | 0.82 | JAK1 (0.39) | JAK2JAK1 | |
| SCHEMBL21776775 | 0.81 | SSTR4 (0.48) | SSTR4SSTR1HCRTR1HCRTR2RBP4 | |
| SCHEMBL21795529 | 0.81 | RBP4 (0.33) | SSTR4SSTR1HCRTR1HCRTR2JAK2 | |
| SCHEMBL21776656 | 0.80 | TLR9 (0.48) | SSTR4SSTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3844159-B1 | NOVEL PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN LA ROCHE (CH) | 2023-05-03 | — | — | EP | disclosed |
| WO-2020043271-A1 | NOVEL PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-03-05 | — | — | WO | disclosed |