Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 19/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1903146 | 0.85 | LTA4H (0.65) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1906988 | 0.83 | LTA4H (0.64) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4688967 | 0.83 | LTA4H (0.64) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4692982 | 0.83 | LTA4H (0.64) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL2170240 | 0.82 | LTA4H (0.62) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11471037 | 0.82 | CYP1A2 (0.73) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2179829 | 0.82 | LTA4H (0.64) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2169641 | 0.80 | LTA4H (0.62) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22224242 | 0.80 | LTA4H (0.62) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1908025 | 0.80 | LTA4H (0.66) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4726238-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| EP-1660492-A1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2006-05-31 | — | — | EP | claimed |
| WO-2005012297-A1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-10 | — | — | WO | claimed |