Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | POLR1A | O95602 | 10/20 | 0.58 |
| ▸ | CASP1 | P29466 | 2/20 | 0.57 |
| ▸ | CASP7 | P55210 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21798952 | 1.00 | ALDH1A1 (0.70) | ALDH1A1KMT2AMEN1POLR1ACASP1 | |
| SCHEMBL21836076 | 0.91 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1POLR1ACASP1 | |
| SCHEMBL21798969 | 0.91 | ALDH1A1 (0.71) | ALDH1A1KMT2AMEN1POLR1ACASP1 | |
| SCHEMBL21798970 | 0.91 | ALDH1A1 (0.71) | ALDH1A1KMT2AMEN1POLR1ACASP1 | |
| SCHEMBL21836072 | 0.90 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1POLR1ACASP1 | |
| SCHEMBL21993198 | 0.90 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1POLR1ACASP1 | |
| SCHEMBL21798990 | 0.89 | POLR1A (0.59) | ALDH1A1KMT2AMEN1POLR1ACASP1 | |
| SCHEMBL21798899 | 0.89 | POLR1A (0.58) | ALDH1A1KMT2AMEN1POLR1AKCNH2 | |
| SCHEMBL21798874 | 0.89 | POLR1A (0.58) | ALDH1A1KMT2AMEN1POLR1ACASP1 | |
| SCHEMBL21798918 | 0.87 | POLR1A (0.61) | ALDH1A1KMT2AMEN1POLR1ACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3632913-A1 | CARBOXYLIC ACID DERIVATIVES OF PYRIDOQUINAZOLINES USEFUL AS PROTEIN KINASE INHIBITORS | Oncostellae, S.L. (ES) | 2020-04-08 | — | — | EP | claimed |
| US-20200079773-A1 | CARBOXYLIC ACID DERIVATIVES OF PYRIDOQUINAZOLINES USEFUL AS PROTEIN KINASE INHIBITORS | ONCOSTELLAE, S.L. (ES) | 2020-03-12 | — | — | US | claimed |
| EP-3632913-A1 | CARBOXYLIC ACID DERIVATIVES OF PYRIDOQUINAZOLINES USEFUL AS PROTEIN KINASE INHIBITORS | Oncostellae, S.L. (ES) | 2020-04-08 | — | — | EP | disclosed |
| US-20200079773-A1 | CARBOXYLIC ACID DERIVATIVES OF PYRIDOQUINAZOLINES USEFUL AS PROTEIN KINASE INHIBITORS | ONCOSTELLAE, S.L. (ES) | 2020-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200079773-A1 | CARBOXYLIC ACID DERIVATIVES OF PYRIDOQUINAZOLINES USEFUL AS PROTEIN KINASE INHIBITORS | MAP4K2, MAP3K1, MAP4K1 | ALDH1A1 2104/4885KMT2A 1192/4885MEN1 3659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.