Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.69 |
| ▸ | CASP7 | P55210 | 6/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.69 |
| ▸ | CASP1 | P29466 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.69 |
| ▸ | HPGD | P15428 | 7/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | GLA | P06280 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | PTGES | O14684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21798961 | 0.85 | KDM4E (0.71) | KDM4ECASP7HSD17B10CASP1ALDH1A1 | |
| SCHEMBL21798938 | 0.84 | KDM4E (0.69) | KDM4ECASP7HSD17B10CASP1ALDH1A1 | |
| SCHEMBL21798898 | 0.84 | KDM4E (0.69) | KDM4ECASP7HSD17B10CASP1ALDH1A1 | |
| SCHEMBL7498198 | 0.84 | KDM4E (0.69) | KDM4ECASP7HSD17B10CASP1ALDH1A1 | |
| SCHEMBL21798922 | 0.84 | KDM4E (0.69) | KDM4ECASP7HSD17B10CASP1ALDH1A1 | |
| SCHEMBL29649777 | 0.83 | KDM4E (0.71) | KDM4ECASP7HSD17B10CASP1ALDH1A1 | |
| SCHEMBL21798989 | 0.83 | KDM4E (0.71) | KDM4ECASP7HSD17B10CASP1ALDH1A1 | |
| SCHEMBL17099654 | 0.83 | KDM4E (0.75) | KDM4ECASP7HSD17B10CASP1ALDH1A1 | |
| SCHEMBL29646595 | 0.83 | KDM4E (0.75) | KDM4ECASP7HSD17B10CASP1ALDH1A1 | |
| SCHEMBL18631335 | 0.82 | KDM4E (1.00) | KDM4ECASP7HSD17B10CASP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3632913-A1 | CARBOXYLIC ACID DERIVATIVES OF PYRIDOQUINAZOLINES USEFUL AS PROTEIN KINASE INHIBITORS | Oncostellae, S.L. (ES) | 2020-04-08 | — | — | EP | disclosed |
| US-20200079773-A1 | CARBOXYLIC ACID DERIVATIVES OF PYRIDOQUINAZOLINES USEFUL AS PROTEIN KINASE INHIBITORS | ONCOSTELLAE, S.L. (ES) | 2020-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200079773-A1 | CARBOXYLIC ACID DERIVATIVES OF PYRIDOQUINAZOLINES USEFUL AS PROTEIN KINASE INHIBITORS | MAP4K2, MAP3K1, MAP4K1 | KDM4E 1110/4885CASP7 1733/4885HSD17B10 3480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.